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Based on the high-throughput gene editing platform, Elem establishes gene knockout cell library, gene knockout cell library and plasmid vector library for pharmaceutical companies in the field of research and development and basic scientific research, and provides high-quality in stock cell-related products and KO-verified antibody products to accelerate the speed of customer research and development.

The high-throughput gene knockout platform has completed the knockout verification of 20000 genes in human primary cells, and more than 80% of the targets have a knockout efficiency of more than 70%. At present, the company has a gene knockout automation and high-throughput production platform, reaching 800 + high knockout efficiency KO cell production capacity per month! You can choose the Elem LM EasyKO kit (RNP method) for efficient knockout according to the instructions. You can also query the in stock cell bank of Elem. Of course, you are also welcome to consult the Elem service team for one-to-one customized service.

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Custom Services

For gene knockout, Elem can provide a series of high value-added services to support cell editing:

1. Expression identification of target genes in target cells: DIA deep proteomics analysis was used, and the number of protein identification was 8000;

2. Necessity of target genes in target cells (ES) analysis: ES analysis can cover tumor cell lines and normal cell lines;

3. Target gene knockout efficiency analysis: provide double guarantee of Sanger sequencing analysis at the gene level and WB/proteomics analysis at the protein level.

For gene knock-in, Elem can provide the following services for customers' application scenarios:

1. Point mutation stable cell line construction;

2. Gene Tagging inserted into stable cell line in situ (N-terminal/C-terminal);

3. Construction of ectopic site-directed insertion of stable cell lines;

4. Construction of multi site integration stable cell line.

For gene knockdown, Elem provides genetic risk assessment based on the exclusive tumor and normal cell necessity database, and provides the following two options:

1. Construction of inducible shRNA stable cell line;

2. Construction of dTAG stable cell lines based on protein degradation: real-time monitoring of phenotypic changes during protein degradation.

Custom Services
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gene knockout

High-throughput gene knockout platform

Elem has an automated, high-throughput gene knockout standardized production platform to achieve a monthly production capacity of 400 + KO cells with high knockout efficiency. Elem's human genome-wide array knockout library has been screened and verified in human primary cells through high connotation screening, and more than 80% of the targets have achieved knockout efficiency of more than 70%.

Gene knock-in

High-throughput gene knock-in platform

Based on the leading high-throughput gene knock-in technology platform, Elem can construct a drug target reporter cell line within 3 weeks, providing cell products and customized services for drug target confirmation, lead compound screening, drug mechanism (MOA) research and other drug development stages. Elem provides different forms of gene knock-in services, such as in situ/ectopic, site-specific/multi-site integration, to serve the different needs of basic scientific research (phase separation, iron death, etc.).

Gene knockdown

High-throughput gene knockdown platform

Based on the human genome-wide knockout experimental data and a large number of bioinformatics support, Elem provides knockdown solutions for essential genes 2000 the genome; Elem-induced shRNA knockdown cell lines can achieve precise targeted gene silencing at the transcriptional level, and are inducible, making the experiment simple and repeatable.

About Us

Elem Biotech focuses on the research and development of high-throughput gene editing tools, serving new drug development and basic research, and providing customers with high-throughput gene knockout, knock-in and knock-down products and services to accelerate the process of drug development and basic research.

22000 + Gene Knockout Experience
67000 + Number of knockout products
2000 + Short-term delivery of KO cell capacity

Granular Creatures

Chinese pioneer in the field of high-throughput gene editing tools

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Elem Biotech is a technology-driven company focused on the development of high-throughput gene editing tools, with a core technical team from the University of California, Berkeley. The company is committed to high-throughput gene editing tools for new drug development and basic research. The Elem team creates a simpler and easier-to-use CRISPR gene knockout tool, freeing you from tedious optimization experiments such as virus packaging, plasmid preparation, Cas9 protein concentration testing, and focusing on biological discovery. The company has completed the verification of high knockout efficiency of 19883 genes in the human genome, and has developed a gene knockout array library of dozens of metabolic pathways, such as kinases and ubiquitin enzymes, for drug target screening and verification.

Granular Creatures
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News

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Technical Topic | Protein Proximity Marker (PL): New Standard for Protein Interaction Research [Collection]]

Technical Topic | Protein Proximity Marker (PL): New Standard for Protein Interaction Research [Collection]]

2024-09-24

Culture and editing of THP-1 cell line of Yiye Zhiqiu I

Culture and editing of THP-1 cell line of Yiye Zhiqiu I

2024-09-24

Market Conference... Elem was invited to participate in the "2024 Annual Meeting of the Intelligent Drugs Committee of the Chinese Pharmaceutical Association"

Market Conference... Elem was invited to participate in the "2024 Annual Meeting of the Intelligent Drugs Committee of the Chinese Pharmaceutical Association"

2024-09-24